López Ruiz


Elena López is a PhD at the University of Granada and an Associate professor at the Department of Physiology, Anatomy and Molecular Biology at the University of Pablo de Olavide, Sevilla. She holds a PhD in Regenerative Biomedicine from the University of Jaén. During her PhD, she focused on the differentiation of adult stem cell toward cardiac and cartilage lineage. She was granted with a Marie Curie fellowship to carry out a research internship at Bath University, UK, with Prof. David Tosh lab, where she got experience in the differentiation of human adipose tissue-derived stem cells (hASCs) towards chondrocytes via adenoviral infections. She carried out an additional research internship at the University of Manchester where she worked on the effect of extracellular matrix proteins on MSCs phenotype. 


Following her PhD, she went to Denmark where she conducted 6 months research at the Interdisciplinary Nanoscience Center (Inano), at Aarhus University. During this period she was involved in the characterization of nanocarriers and the in vitro evaluation of delivery and gene silencing in chondrocytes.  


Elena has been working on several projects related to tissue regeneration and cell therapy. Recent work includes the in vitro and in vivo study of the chondrogenic differentiation of dedifferentiated chondrocytes and infrapatellar fat pad stem cells from osteoarthritis patients by novel chimeric growth factors. In addition, she has worked in the cardiac differentiation of endothelial progenitors cells isolated from peripheral blood of patients with acute myocardial infarction and from umbilical cord blood (UCB). She is also interested in the endothelial regeneration of a vascular tissue engineering vessel by using decellularized polymer-coated arteries and 3D bioprinting. Currently, she is also analyzing the anticancer effects of an enzyme drug on the pancreas and ovarian cancer especially aimed to target tumour cancer stem cells. More specifically, she evaluates CSCs-related genes and/or pathways involved in drug resistance and tumour metastasis. To do so she apply several biotechnological techniques, including in vivo xenograft models and in vitro assays such as isolation and characterization of cancer stem cells from tumour cell lines. 

She teaches Human Anatomy at the undergraduate level in the Faculty of Sciences (University of Pablo de Olavide). Her post-graduate teaching is in the Translational Research and Personalized Medicine (TransMed). Elena has supervised three Master's thesis involves in the field of the 3d bioprinting. She serves as a reviewer for top journals and as editor.